CD274 and neoplasm: With increased tumor PD-L1, expression of activation and cytotoxicity marker genes, including IFNG, TNFSF9, TNFSF14, CSF2, and IL2, were downregulated in both Tnull and TCR-TMART-1 (Figure 4A), consistent with results of cytokine secretion assays (Figure 1F-G).