CD274 and neoplasm: TCR-TMART-1 was affected more than Tnull by increased tumor PD-L1 levels (Figure 3E, S3C), and TCR-TMART-1 targeting PD-L1low tumors expressed higher levels of not only activation genes, such as XCL and TNFRSF9, but also anti-inflammatory genes, such as DUSP439 and MIF40, compared to the TCR-TMART-1 targeting PD-L1int and PD-L1high tumors (Figure 3E, 3F).