But OICR-9429 was less cytotoxic to normal prostate cells WPMY-1 characterized by low WDR5 expression, and WDR5 knockdown PCa cells, suggesting that OICR-9429 could selectively inhibit PCa cells with a WDR5 dependent manner (Figure 4A and Figure S5A-B). The gene discussed is WDR5; the disease is posterior cortical atrophy.