Considering that transendothelial dextran transport is a direct reflection of VBMEC permeability, and that ROCK1, RhoA, and MLC are key molecules in regulation of the cell cytoskeleton, we suggested that CX3CL1 can effectively upregulate VBMEC permeability in an ICAM-1-dependent manner, which led to the increased transendothelial migration of NSCLC cells. Here, ICAM1 is linked to non-small cell lung carcinoma.