CX3CL1 and non-small cell lung carcinoma: However, following administration of ICAM-1 overexpression, the number of adhered cells remarkably increased in the CX3CL1-KD group, and there was no significant discrepancy between the ICAM-1-overexpression and control VBMEC groups, indicating ICAM-1 as a main downstream effector in CX3CL1-induced NSCLC cell adhesion (Figure 4E and 4G).