CX3CL1 and non-small cell lung carcinoma: Furthermore, ICAM-1-overexpression treatment in VBMECs rescued the efficacy of CX3CL1-KD inhibition of NSCLC cell transendothelial migration, indicating ICAM-1 signaling was required for CX3CL1-mediated NSCLC cell transendothelial migration (Figure 5B-C, and Figure S4A-B).