Similar observations were found with phosphorylation levels of PI3K and AKT, protein levels of MMP-2, and mRNA levels of Icam-1 and Gef-h1 within spine-metastatic lesions of mice, confirming the rescue effect of LFA-1-overexpression on NSCLC spinal metastases to CX3CR1-KD treatment (Figure 7F and 7I). The gene discussed is ARHGEF2; the disease is non-small cell lung carcinoma.