Considering that NSCLC cells promoted CX3CL1 shedding from VBMECs by activating MAPK14/ADMA17 signaling, we suggested that NSCLC cells stimulated CX3CL1 secretion from VBMECs not only by enhancing MAPK14/ADMA17-mediated protein release but also by promoting NF-κB-dependent CX3CL1 synthesis. Here, MAPK14 is linked to non-small cell lung carcinoma.