This means that NSCLC cells interacted with VBMECs to regulate CX3CL1 production in two ways: by promoting CX3CL1 gene expression via the NF-κB pathway and by enhancing soluble CX3CL1 secretion via MAPK14/ADAM17 signaling. This evidence concerns the gene CX3CL1 and non-small cell lung carcinoma.