Notably, addition of platelets to the system elicited a robust increase in the number of adhered cells in control VBMEC groups, which was abolished by genetic silencing of CX3CL1 in VBMECs, suggesting that platelets provided NSCLC cell adhesion advantages in a CX3CL1-dependent manner. Here, CX3CL1 is linked to non-small cell lung carcinoma.