Interestingly, when the ICAM-1 gene was overexpressed in VBMECs, the adhesion disadvantages of NSCLC cells conferred by LFA-1 silencing were evidently attenuated, rescuing the ability of LFA-1 KD to decrease NSCLC cell adhesion to VBMECs (Figure 4H-J and Figure S3F-H). This evidence concerns the gene ICAM1 and non-small cell lung carcinoma.