AKT1 and non-small cell lung carcinoma: Co-culture with conditioned media of VBMECs effectively promoted PI3K and AKT phosphorylation in A549 cells without obvious changes in the total PI3K and AKT expression levels, indicating the involvement of PI3K and AKT phosphorylation in VBMEC-mediated promotion of the invasive capability of NSCLC cells (Figure 2E).