Additionally, considering that CX3CL1 induced more circulating NSCLC cells to contribute to CTC-VBMEC interactions by promoting their adhesion to VBMECs, it is conceivable that CX3CL1 also promoted itself production by driving positive feedback during the vicious cycle in response to circulating NSCLC cell stimulation. The gene discussed is CX3CL1; the disease is non-small cell lung carcinoma.