Similar observations were found with Icam-1 and Gef-h1 mRNA levels within spine-metastatic lesions of mice injected with CX3CL1‐KD, LFA-1-KD, and CX3CR1-KD and LFA-1-KD NSCLC cells, indicating reduced permeability of VBMECs induced by disengagement of the CX3CL1/ICAM-1-mediated cycle (Figure S5I). Here, CX3CR1 is linked to non-small cell lung carcinoma.