ARHGEF2 and non-small cell lung carcinoma: In the present study, we found that VBMECs effectively induced NSCLC cell adhesion in coordination with platelets through the CX3CL1/ICAM-1/LFA-1 pathway, and that CX3CL1/ICAM-1 signaling remarkably increased VBMEC permeability via activating the Src/GEF-H1 pathway.