Meanwhile, overexpression of ICAM-1 also significantly increased the number of adhered tumor cells and reversed the adhesion disadvantages of NSCLC cells conferred by CX3CL1-KD treatment in the presence of platelets, highlighting the dependent role of ICAM-1 in platelet-assisted NSCLC cell adhesion (Figure 4F-G). This evidence concerns the gene ICAM1 and neoplasm.