Meanwhile, CX3CL1/ICAM-1 molecules enabled circulating NSCLC cell adhesion to VBMECs in cooperation with platelets by activating the CX3CL1/ICAM-1/LFA-1 pathway and drove NSCLC cell transendothelial migration by improving permeability of VBMECs through the Src/GEF-H1 pathway. Here, CX3CL1 is linked to non-small cell lung carcinoma.