To clarify the role of AMPKα in activation of GPR43-mediated podocyte insulin resistance, we determined the effect of AMPKα activity restoration induced by an AMPK agonist (5-aminoimidazole-4-carboxamide ribonucleotide, AICAR) on podocyte insulin resistance mediated by GPR43 activation. This evidence concerns the gene FFAR2 and Insulin resistance.