Moreover, Salem et al found that microsatellite stable (MSS) colorectal carcinomas (CRCs) had a lower absolute incidence of KMT2D mutations than MSI-H CRCs 47, and KMT2D is a homologous recombination gene 48, implying that KMT2D mutations are associated with genomic instability. The gene discussed is KMT2D; the disease is colorectal carcinoma.