Previous studies also found that HOXA-AS2 was significantly up-regulated in multiple tumor tissues, including pancreatic 38, gastric 39, breast 40, 52, and bladder cancer 41, glioma 42, papillary thyroid cancer 43, 44, osteosarcoma 45, non-small lung cancer 46, gallbladder carcinoma 47, colorectal cancer 48, 49, 53, and hepatocellular carcinoma 50, 51. This evidence concerns the gene HOXA-AS2 and thyroid gland papillary carcinoma.