MAPK1 and acute myeloid leukemia: In the present study, we performed enrichment analyses of DEGs in AML patients with different expression levels of HOXA-AS2, which also demonstrated that HOXA-AS2 plays an essential role in AML via the PI3K-Akt, ERK, and MAPK pathways regulation, as well as by affecting cell adhesion, cell differentiation, cell migration, angiogenesis, and cell proliferation biological processes.