AKT1 and central nervous system cancer: Gao et al. suggested that HOXA-AS2 achieved its oncogenic function and angiogenesis in gliomas via the miR-373/epidermal growth factor receptor (EGFR)/VE-cadherin, matrix metallopeptidase 2 (MMP2) and MMP9/PI3K-Akt signaling pathway axis 42.