Regarding other important molecular mechanisms, HOXA-AS2 promoted cell proliferation through the HOXA-AS2/enhancer of zeste homolog 2 (EZH2)/cyclin-dependent kinase inhibitor 1A (also known as P21), polo-like kinase 3, DNA damage-inducible transcript 3 axis in gastric cancer 39, the HOXA-AS2/EZH2/lysine-specific demethylase 1 (LSD1) in pancreatic cancer 38, and the HOXA-AS2/EZH2 and LSD1/P21 and Kruppel-like factor 2 axis in colorectal cancer 49. This evidence concerns the gene PLK3 and colorectal cancer.