FLT3 and acute myeloid leukemia: In contrast, GSEA analysis using the c2 (c2.all.v6.2.symbols.gmt) gene set revealed gene signatures related to up-regulated in pediatric AML with mutated NPM1, AML with internal tandem duplications (IDT) in fms-related tyrosine kinase 3 (FLT3), targets of nucleoporin 98 (NUP98)-homeobox A9 (HOXA9) fusion, AML cluster, erythroid differentiation, and response to oxidized phospholipids (Figure 4A-L).