These pathways included those involving p53, microRNAs, thyroid hormone and Hedgehog; as well as those regulating pluripotency of stem cells, mismatch repair, base excision repair, nucleotide excision repair, glutathione metabolism, small cell lung cancer; and many immunological pathways involving Fc epsilon RI, hepatitis C, complement and coagulation cascades, NF-kappa B, TNF, and autoimmune responses. The gene discussed is TNF; the disease is hepatitis C virus infection.