B-cell lymphoma 2 (Bcl-2) has been reported as one of the targets of miR-15a/16 in CLL and prostate cancer, and inhibition of cell proliferation by miR-15a/16 through Bcl-2 has been reported in both lymphoid and non-lymphoid tissues 29, 40. This evidence concerns the gene BCL2 and B-cell chronic lymphocytic leukemia.