CCN1 and colorectal carcinoma: To assess the role of Cyr61 in the resistance of CRC cells to L-OHP, the levels of Cyr61 in HCT-8/L-OHP and HCT116/L-OHP cells were decreased with shCyr61 (Figure 3A and D); these cells were named HCT-8/L-OHP-shCyr61 cells and HCT116/L-OHP-shCyr61 cells, respectively.