BIRC5 and colorectal carcinoma: To explore the molecular mechanism underlying the antiapoptotic effects of Cyr61 in L-OHP-resistant CRC cells, we first evaluated the levels of Bcl-2, Bcl-xL, XIAP, and Survivin; the results showed that the Bcl-xL mRNA and protein levels in HCT-8/L-OHP cells were significantly higher than those in HCT-8 cells, while no significant difference was found in the mRNA levels of Bcl-2, XIAP, and Survivin (Figure 5A).