The results showed that L-OHP-induced apoptosis was enhanced by knockdown of Cyr61 in HCT-8/L-OHP and HCT116/L-OHP cells (Figure 4A and B), indicating that Cyr61 is involved in the resistance of CRC cells to L-OHP by decreasing L-OHP-induced apoptosis. Here, CCN1 is linked to colorectal carcinoma.