Surprisingly, in contrast to most of malignancies, FSCN1 was found to be down-regulated in two independent GSE datasets in MM (GSE39754 and GSE2113, Fig 1), and high expression of FSCN1 was closely related to longer OS in MM, which was confirmed in 973 patients from GSE24080 and GSE4581 (Table 1, Fig 2). This evidence concerns the gene FSCN1 and Miyoshi myopathy.