Our results revealed that xenografts of HCC cells transfected with shAR plasmid (Group 2) had more progression than control group (Group 1), and oemiR-325 could partly reverse in vivo function of knocking down AR (Figure 7A), we also count the mice with metastasis tumors, the results also showed that knocking down AR could promoter tumor metastasis (Figure 7B), and we also counted the metastatic foci in each mice, the results showed the same tendency with Figure 7B (Figure 7C), what's more, the IHC data of ACP5 expression also confirmed our conclusions (Figure 7D). The gene discussed is AR; the disease is neoplasm.