As shown in Figure 3A, compared to DDP treatment alone, JP3 in combination with DDP significantly increased γ-H2AX level in DDP-resistant GC cells; on the contrary, expressions of XRCC1/p-XRCC1, CK2α and Bcl-2 were down-regulated in DDP-resistant GC cells. This evidence concerns the gene H2AX and gastric cancer.