Then, the diagnostic value of the 10 core genes in NPC was evaluated via GSE12452 dataset and we found that the area under the curve (AUC) of nine core genes (FN1, MMP1, MMP3, PLAU, PLAUR, SERPINE1, SPP1, COL8A1, COL10A1) were all more than 0.8 (P < 0.05, Fig. 11B, Table 5) and among them, the AUC of FN1 and PLAU were close to 1. This evidence concerns the gene SPP1 and nasopharyngeal carcinoma.