By analyzing genetic alterations of the 10 core genes in NPC via cBioPortal database, we found that MMP1 (7%), MMP3 (7%) and SERPINE1 (6%) had the highest frequency of alterations in the 10 core genes (Fig. 8B) and the alterations of the 10 core genes occurred in 123 (24%) of 504 patients (Fig. 8C). The gene discussed is MMP1; the disease is nasopharyngeal carcinoma.