Then we found that 5 of the 10 core genes had influence on the survival of NPC patients, including MMP1 (HR = 1.3, P = 0.04700), PLAU (HR = 1.6, P = 0.00054), PLAUR (HR = 1.4, P = 0.00920), SERPINE1 (HR = 1.5, P = 0.00250) and SPP1 (HR = 1.3, P = 0.04600) (Fig. 10). The gene discussed is MMP1; the disease is nasopharyngeal carcinoma.