CD19 and acute lymphoblastic leukemia: Furthermore, a clinical trial evaluating the feasibility, safety and biological effect of adoptive transfer of donor-derived EBV-specific cytotoxic T-lymphocytes (EBV-CTL) transduced with a gamma-retroviral vector encoding a first generation CD19-specific CAR construct for the treatment of patients with high-risk or relapsed B-cell precursor ALL after allogeneic hematopoietic stem cell transplantation was conducted in Germany and the UK (NCT01195480).