Retroviral insertions within the MECOM (MDS1-EVI1) locus led to clonal outgrowth of hematopoietic clones that resulted in formation of myelodysplastic syndromes (MDS) that likely evolved to AML in one patient and refractory cytopenia with multilineage dysplasia in the second patient [103]. Here, MECOM is linked to acute myeloid leukemia.