Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) protein deubiquitinates and upregulates NOX4 to generate H2O2 and the overexpression of UCH-L1 promoted the invasive potential of the B16F10 lung cancer cell line via regulating the upstream kinase Akt, suggesting that ROS are related to cancer aggressiveness in various pathways66. The gene discussed is UCHL1; the disease is lung carcinoma.