EO-CRC showed a higher frequency of TP53 mutation (80% vs 72%, Fisher’s exact P = 0.03) and lower frequencies of APC (65% vs 78%, P < 0.001) and KRAS (37% vs 45%, P = 0.01) mutation than LO-CRC (Fig. 2). The gene discussed is KRAS; the disease is colorectal carcinoma.