Our data showed that the AC + AA genotype of rs12711521 and the GT + GG genotype of rs7548659 was more prevalent in TB patients than healthy controls, which demonstrated that the rs12711521 and rs7548659 of MASP2 gene were related to the increased susceptibility of TB, while no such association was found in the rs12142107 of MASP2 gene. Here, MASP2 is linked to tuberculosis.