CRPM were better at separating OA from E-RA than CRP with an AUC difference (SE) of 0.08 (0.04), p = 0.036, and OA from MS-RA 0.02 (0.01), p = 0.02 (Fig. 2, Tables S2 and S3). This evidence concerns the gene SH3BP2 and rheumatoid arthritis.