Interestingly, we also included OA patients in the analysis that approximately 25% of the OA patients clustered with a subset of RA patients which were primarily in bone and cartilage markers, whereas about 10% of the patients clustered with RA patients that were high in bone, cartilage, macrophage and interstitial matrix turnover markers including CRPM. The gene discussed is SH3BP2; the disease is rheumatoid arthritis.