Another study showed that β1 adrenergic receptor (ADRB1) mRNA was found exclusively in α-cells, while ADRB2 were expressed in α-cells as well as a number of other endocrine islet cells66. Our RNA-seq and Nanostring data showed expression of adrenergic receptors was decreased in microdissected T1D islets however, their expression levels were near the minimum cut-off levels for both assays. This evidence concerns the gene ADRB2 and type 1 diabetes mellitus.