CCND1 and neoplasm: Abundant evidence suggests that STAT3 contributes to cancer cell proliferation, survival, tumor angiogenesis, invasion, migration and resistance to apoptosis, since the activated STAT3 complex translocates to the nucleus to regulate STAT3 target gene expression that is involved in the cell cycle (Cyclin D1 and c-Myc), survival (Survivin, Bcl-xL and Bcl-2), angiogenesis (VEGF), and invasion/migration (MMP-2)10–12.