This corroborated the previous finding that KRAS G12C mutations are more frequent in patients with MUTYH-associated polyposis29, an autosomal recessive disease form of COAD caused by biallelic loss-of-function mutations to the gene encoding the DNA glycosylase, MUTYH, responsible for clearing 8-oxoguanine:A mismatches that can cause the G12C mutation. This evidence concerns the gene MUTYH and colon adenocarcinoma.