We validated the DisCo approach with disease-relevant condensates formed by FUS, associated with familial amyotrophic lateral sclerosis (ALS) and frontotemporal lobal degeneration (FTLD)31, and an expanded polyglutamine (72Q)-containing huntingtin Exon 1 associated with Huntington’s disease pathology32. This evidence concerns the gene HTT and amyotrophic lateral sclerosis.