Indeed, the lysosomal enzyme GBA1 which encodes for β-glucocerebrosidase (GCase) and catalyzes the hydrolysis of glucosylceramide (GlcCer) to glucose and ceramide, represents the greatest genetic risk factor for PD, with GBA1 mutation carriers exhibiting more severe cognitive symptoms11,12. The gene discussed is GBA1; the disease is Parkinson disease.