Interestingly, a recent study also indicated that Mct-1 activation facilitates the release of multiple cytokines, such as interleukin-6, monocyte chemotactic protein 1, and granulocyte-macrophage colony-stimulating factor via interacting with miR-34a, and is also highly correlated to the recruitment of tumor-associated macrophages (TAMs), especially accumulation of the tumor-promoting M2 type32. This evidence concerns the gene CCL2 and neoplasm.