CASP3 and pulmonary fibrosis: Previous studies also showed that Retnla induced myofibroblast differentiation and Retnla treatment inhibited tumor necrosis factor-α-induced activities of caspase-3 and caspase-8, indicating that Retnla might contribute to the pathogenesis of pulmonary fibrosis by induction of fibroblast resistance to apoptosis10,34.