FGF21 and posterior cortical atrophy: The limitations of this study are: (1) we could not determine the direct biological effects of FGF21, as there are differences between in vitro experiments and the human internal environment; (2) the effect of endogenous FGF21 on PCa remains unclear and requires further study; (3) KEGG analysis of the signaling pathway was performed on mouse adipose tissue, which may be different from prostate tissue.