BCL2 and lip and oral cavity carcinoma: CERS1 uses C18-acyl-CoA, which is related to oral cancer cell autophagic cell death.43 CER can reduce protein kinase B (AKT) activity by activating protein phosphatase 2 A (PP2A), p3844 and protein kinase C (PKC),45 and then AKT reduces the phosphorylation level of BCL2.44,46 Finally, the decreased level of BCL2 and the ratio of BCL2 to BAX leads to cell death.