CERS1 uses C18-acyl-CoA, which is related to oral cancer cell autophagic cell death.43 CER can reduce protein kinase B (AKT) activity by activating protein phosphatase 2 A (PP2A), p3844 and protein kinase C (PKC),45 and then AKT reduces the phosphorylation level of BCL2.44,46 Finally, the decreased level of BCL2 and the ratio of BCL2 to BAX leads to cell death. Here, PTPA is linked to lip and oral cavity carcinoma.