NFKB1 and osteoporosis: Beyond the solid connection between primary osteoporosis and angiogenesis, secondary osteoporosis, such as glucocorticoid-induced osteoporosis (GIO), must not be ignored.212 Indeed, glucocorticoids exert major impacts on vasculature alterations and osteogenesis impairment during bone growth and development.213 By inhibiting preosteoclast-secreted PDGF-BB through transrepression of the NF-κB pathway, glucocorticoids lead to a reduction in type H vessel abundance and blood flow supply, accompanied by osteoprogenitor dysfunction.