The adhesion molecules ITGA6 (integrin subunit alpha 6) and GPR56 (adhesion G protein-coupled receptor G1) are highly expressed in EVI1-positive AML, and their knockdown leads to increased apoptosis in response to Ara-C treatment and loss of RhoA (ras homolog family member A) signaling, respectively71,72. Here, RHOA is linked to acute myeloid leukemia.