MECOM and acute myeloid leukemia: Recently, the small molecule compound pyrrole-imidazole polyamide, which inhibits the DNA-binding activity of N-terminal ZF domain of EVI1, was shown to induce apoptosis of EVI1-expressing AML cells due to downregulation of the EVI1 target GRP56, which was linked to EVI1-mediated resistance to apoptosis71.