In a transgenic mouse model recapitulating human inv3(q21q26) AML that overexpresses EVI1 and also has GATA2 haploinsufficiency, EVI1 and GATA2 dysregulation together skewed hematopoiesis toward the megakaryocyte lineage more so than EVI1 overexpression alone21. This evidence concerns the gene MECOM and acute myeloid leukemia.