For patients with advanced hepatocellular carcinoma (HCC), the combination of atezolizumab (anti-PD-L1 ICI) and bevacizumab (anti-angiogenic agent) demonstrated superior OS, PFS, and objective tumor response, compared with the multikinase inhibitor sorafenib, and establishes a new standard of first-line systemic therapy for advanced HCC.2 Here, CD274 is linked to hepatocellular carcinoma.