HARS1 and Charcot-Marie-Tooth disease: So far, five aaRSs (i.e., glycyl [GlyRS or GARS1]-, tyrosyl [TyrRS or YARS1]-, histidyl [HisRS or HARS1]-, alanyl [AlaRS or AARS1]-, and tryptophanyl [TrpRS or WARS1]-tRNA synthetases) have been unequivocally linked to the disease, constituting the largest gene family implicated in CMT (2, 3).