Development of neurodegenerative diseases is sometimes associated with dysfunction of the intracellular trafficking apparatus (Ferrucci et al., 2011; Majcher et al., 2015; Dahm and Macchi, 2007) and in human as well as in mouse, mutations in the SCYL1, SCYL2 and SCYL3 genes have been linked to amyotrophic lateral sclerosis (ALS) and other neuronal dysfunction and activity (Pelletier et al., 2012; Schmidt et al., 2015; Kuliyev et al., 2018). The gene discussed is SCYL1; the disease is amyotrophic lateral sclerosis.