In order to check if this trend was only related to a specific effect of Doxo treatment on exosomes release of APE1 or whether it was common to other genotoxic treatments, JHH-6 cells were treated with Cisplatin (CDDP), a DNA-cross-linking agent commonly used in the treatment of NSCLC (56, 57). Here, APEX1 is linked to non-small cell lung carcinoma.