In these studies, we used the EAE model, as well as the cuprizone-induced demyelination model on GFAP-tTA;TRE-IFN-γ double-transgenic mice, which ectopically express interferon gamma (IFN-γ) in the CNS in a regulated manner (Lin et al., 2004; Lin et al., 2005). The gene discussed is IFNG; the disease is Peripheral demyelination.