In the case of glioblastomas, it has been reported that P4 and E2 increased the expression of proteins closely associated with angiogenesis and cell proliferation, such as vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), and Cyclin D1 in human glioblastoma derived cell lines. The gene discussed is EGFR; the disease is glioblastoma.