Furthermore, general, or more specific, clinical scores (such as for example the American Society of Anaesthesiologists’ (ASA) score, Alvarado’s score in case of acute appendicitis, SOFA for sepsis), the age of the patient and the presence of comorbidities, such as obesity, diabetes and COPD, can assist the emergency surgeon’s decision making process, associated with clinical (signs of localized or generalized peritonitis at abdominal examination) and biological (inflammatory biomarkers such as C-reactive protein, procalcitonin, lactates) parameters. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.