CLOCK and neoplasm: In a recent study, when mice with Lewis lung carcinoma were treated with doxorubicin, they exhibited a significant alteration in the expression of F4/80 and CD11c in tumor tissues, and in the expression of circadian genes, including Bmal1, Clock, Rev-Erbα, and Per2 and NF-kB and IL-6 in intraperitoneal macrophages [120].