The current literature on the prognostic capacity of testosterone and SHBG in women is inconclusive, with some studies suggesting a U-shaped relationship with the implication that those with the lowest or the highest levels have an impaired survival15,16 while other investigations are devoid of any prognostic association.17, , –20 The main results from a recent report from the Multi-Ethnic Study of Atherosclerosis (MESA; n = 2834 postmenopausal women) showed that higher total testosterone was associated with increased risk of cardiovascular disease. Here, SHBG is linked to cardiovascular disorder.