The prognostic effect of SHBG is in part supported by other studies6,16,21 and in a subgroup analysis from the MESA report excluding women on hormone therapy (n = 1934), high levels of SHBG and low levels of free testosterone and estradiol were related to an elevated risk of coronary heart disease.9 The present lack of an association between the hormones and cardiovascular disease may relate to the discrepant study populations. The gene discussed is SHBG; the disease is cardiovascular disorder.