SPINT1 and cancer: Hence, SPINT1 has been reported as a pan‐cancer suppressor and a potential therapeutic target because of its inhibitory effect on carcinogenesis, invasion, and metastasis in esophageal,17 gastric,18 colorectal,14 breast,19, 20 lung,21 ovarian,22 cervical,23 prostate,24, 25 pancreatic,26, 27, 28 endometrial,17 renal,29 and oral squamous cell carcinoma cancers.16