Even though both MACC1 and SPINT1 were validated to be associated with the HGF/c‐Met signaling pathway in multiple cancer types, synergistic regulations of MACC1 and SPINT1 in the context of the HGF/c‐Met signaling axis and the potential pan‐cancer prognostic value of these two gene combinations remain to be investigated. The gene discussed is MACC1; the disease is cancer.