Increased expression of TNF‐related apoptosis‐inducing ligand (TRAIL) is observed in mesenchymal stem cell‐derived exosomes, which after interaction with death receptors 4/5 (DR4/TNFRSF10A: DR5/TNFRSF10B) mediates apoptosis specifically in cancer cells (Yuan et al., 2017). The gene discussed is TNFRSF10B; the disease is cancer.