For example, in MS, the Class II HLA-DRB1*15:01~HLA-DQB1*06:02~a1, or (H+), haplotype is the genetic trait with the largest (by far) disease-association of any in the genome (for the WTCCC: OR = 3.28; p<<10−300). The gene discussed is HLA-DRB1; the disease is myeloid sarcoma.