For instance, Li et al. (2006) [13], Mitchell et al. (2016) [14], and Ho et al. (2018) [15] reported diethylnitrosamine (DEN)-induced HCC in pigs, whereas Schachtschneider et al. (2017) [16] reported a translational porcine model of HCC by introducing mutations in TP53 and KRAS oncogenes. Here, KRAS is linked to hepatocellular carcinoma.