The effect of EZH2 knockdown on proliferation was evaluated in HCC-1187 and MDA-MB-231, and EZH2 knockdown decreased proliferation in HCC-1187 cells (Fig. 3i) but did not change proliferation in MDA-MB-231 cells (Fig. 3j), suggesting that the decrease in proliferation in HCC-1187 cells may at least in part be due to the increase in PTEN expression. The gene discussed is PTEN; the disease is hepatocellular carcinoma.