UNC1999 restored PTEN expression considerably in the HCC-1187, HCC-1954, and HCC-2218 cell lines, restored it weakly in MDA-MB-175-VII, but did not in the MDA-MB-231 or HCC-1143 cell lines (Fig. 4a–f), and these results were consistent with our EZH2 stable knockdown experiments. The gene discussed is PTEN; the disease is hepatocellular carcinoma.