First, we found that while expression of ASCL1 and NEUROD1 seems to be mutually exclusive in cell lines, they seem to co-express in many of the tumor samples; a small set of samples with low NE scores still express ASCL1 or NEUROD1; in “George_2015”, “Jiang_2016” and our own data set, we have observed rare POU2F3+ samples that have high NE scores. The gene discussed is ASCL1; the disease is neoplasm.