IFNG and neoplasm: These gene sets include the following: SPARCS genes (stimulated 3 prime antisense retroviral coding sequences) reported to express in mesenchymal tumors and mediate interferon-gamma signal amplification27; “parainflammation” genes in epithelial tumor cells38; and senescence-associated secretory phenotype (SASP) genes39 that reinforce the senescence arrest, alter the microenvironment, and trigger immune surveillance of the senescent cells40.