Regarding other hypertensive models, cardiac ACE2 was unchanged at the mRNA level in stroke-prone SHRs (SHR-SP), Ren2-transgenic (tg) mice, or hRN/hANG-tg mice [41–43] and at the protein level in AngII-infused C57BL/6 mice [44]. Here, ZNF699 is linked to stroke disorder.