ACE and Hypertension: Among 28 (40 experiments) of 102 disease models, ACE expression was repressed to less than half the control levels in the heart (hypertension, heart failure, and pressure-overload models), kidneys (hypertension, CRF, and diabetes models), arteries (AngII infusion and vascular injury models), lungs (silicosis model), and other organs (Table 1).