Among 28 (40 experiments) of 102 disease models, ACE expression was repressed to less than half the control levels in the heart (hypertension, heart failure, and pressure-overload models), kidneys (hypertension, CRF, and diabetes models), arteries (AngII infusion and vascular injury models), lungs (silicosis model), and other organs (Table 1). This evidence concerns the gene AGT and hypertensive disorder.