Baseline ACE2 overexpression was observed in the heart of MI (infarct/border myocardium) and SAS models [60, 61, 72], in aortic atherosclerotic plaques [94], in the kidneys of AKI, drug injury, and UUO-induced fibrosis models, [67, 69, 84–86], and in the liver of BDL- or CCl4-induced fibrosis models [103, 104]. This evidence concerns the gene ACE2 and fibrosis.