We also surveyed the expression profiles of the entire NR superfamily in 3D-cultured prostate cancer stem- or progenitor-like cells (PCSCs) and castration-relapse xenografts (VCaP-CRPC), and identified some ONRs (including RORβ, TLX, COUP-TFII, NURR1 and LRH-1) that show significant common up-regulation in 3D-cultured PCSC-enriched prostatospheroids and CRPC xenografts [24]. The gene discussed is NR5A2; the disease is prostate carcinoma.