ESRRA and Familial prostate cancer: It is worth noting that the three ONRs can target both common (e.g., CYP17A1 by LRH-1 and SF-1, CYP11A1 by LRH-1 and ERRα) and specific steroidogenic enzyme genes, and therefore be involved in distinct pathways of androgen biosynthesis in prostate cancer, in which ERRα and SF-1 participate in both front-door and backdoor pathways of DHT biosynthesis, whereas LRH-1 is responsible for the similar pathways except the secondary backdoor pathway.