NR5A2 and Familial prostate cancer: More importantly, LRH-1 can promote breast carcinogenesis by increasing the local estrogen production in adipose stroma surrounding breast carcinomas via its transactivation of the aromatase gene (CYP19A1) [53], suggesting indirectly that LRH-1 may play a positive role in the development of prostate cancer that is also influenced by the microenvironment containing sex steroids.