Moreover, when the wild-type and bmp8a−/− zebrafish were infected with turbot skin verruca disease virus (TSVDV) isolated from skin (Supplementary Fig. 2), death occurred in bmp8a−/− zebrafish at 108 h of post-infection, and all the fish died at 156 h of post-infection, while none of the wild type zebrafish were dead during the period (Fig. 1l). Here, BMP8A is linked to infection.