AHR and colitis: Although the role of the AhR in endocrinology has not yet been clarified, an endogenous ligand of AhR, 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester (ITE), has been isolated from lung tissue22 and confirmed to reduce colitis through induction of regulatory T cells and treat autoimmune diseases23, also suppressing angiogenic responses of human umbilical artery endothelial cells in vitro through an AhR-dependent pathway24.