Interestingly, LRRK2 M2397T is associated with Paneth cell defects in Japanese CD patients as the number of M2397T alleles negatively correlates with number of normal Paneth cells and pathway analysis suggests this may be due to defects in autophagy76, one of the many pathways in which LRRK2 has been implicated. Here, LRRK2 is linked to Cowden disease.